Rooted in cutting-edge genetic science and community responsibility, the project enables early identification of inherited disease risks, empowering individuals and families to make informed decisions that protect future generations.
Scientific Foundation: From Undiagnosed Disease to Prevention
More than 15 years ago, Hadassah hospitals launched an Undiagnosed Patients Program to uncover the genetic causes of diseases that did not fit known clinical categories. Under the leadership of Prof. Orly Elpeleg, then Head of Hadassah hospitals’ Department of Genetics, this work led to the identification of over 100 previously unknown disease-causing gene variants.
These discoveries were consolidated into HADASSOME, a unique database linking genetic variants to clinical conditions. This foundational work positioned Hadassah as a global leader in rare disease genetics and precision medicine.
A Community-Based Genetic Model in Mexico
Building on a long-standing relationship between Hadassah Hospitals and the Mexican Jewish community, the Mexican Genetic Project was established to apply this expertise at a population level.
Through voluntary participation, over 800 couples have now taken part in genetic compatibility screening, with more than 300 exomes—the protein-coding regions of DNA—sequenced and analyzed in the initial phases alone.
Although exomes comprise only 1–2% of human DNA, they contain approximately 85% of known disease-causing mutations, making them a powerful tool for identifying inherited risks.
Why Prevention Matters
“For rare genetic diseases, prevention is often the only effective approach,” Prof. Elpeleg emphasized, noting that 95% of rare genetic disorders currently have no curative treatment.
The project focuses on:
- Identifying founder mutations common within specific populations
- Informing couples when both partners carry the same disease-causing variant
- Enabling preventive pathways, including prenatal or preimplantation testing
- Highlighting secondary “actionable” findings that allow early medical monitoring
In early project phases, approximately 15% of participants received information with life-changing medical significance—ranging from reproductive risk to predispositions for cardiac conditions or cancer, enabling early surveillance and intervention.
Impact Beyond Genetics
The Mexican Genetic Project is not only a medical initiative—it is a model of communal responsibility and education.
Participants gain a deeper understanding of genetics, inheritance, and preventive health. Community events and educational forums have reinforced awareness among younger generations about the genetic considerations involved in family planning.
As Prof. Elpeleg observed, “What the Mexican Jewish community has done is truly cutting-edge. This is a community that cares for one another.”
Ongoing Leadership and Global Expansion
Today, the project continues under the leadership of Dr. Tamar Harel, Director of Hadassah hospitals’ Department of Genetics, with plans to expand similar models in collaboration with Hadassah leadership in Panama and Australia, extending the reach of preventive genetic medicine to additional communities.
The success of the project has been made possible by:
- The clinical and research excellence of Hadassah hospitals’ genetics teams
- The engagement and trust of the Mexican Jewish community
- The coordination and global vision supported by Hadassah International
- A dedicated network of volunteers and philanthropic partners
A Model for the Future
The Mexican Genetic Project demonstrates how precision medicine, when combined with community engagement and ethical responsibility, can change lives before illness begins.
It stands as a replicable model for communities worldwide—one that transforms advanced genetic science into practical prevention, education, and healthier futures.
